Global Journal of Medical Research, F: Diseases, Volume 22 Issue 1

Optimization of Treatment Methods for Purulent- Destructive Soft Tissue Diseases through the use of Laser Treatment Methods Teshaev Oktyabr Rukhullaevich α , Muradov Alijon Salimovich σ & Mavlyanov Olimboy Razzokovich ρ Abstract- Purpose: Optimization of methods for the treatment of purulent-destructive diseases through the complex application of photodynamic therapy (PDT) and CO 2 laser. Materials and Methods: 360 patients with purulent-destructive soft tissue disease were examined and treated. Depending on the treatment carried out, the patients were conditionally divided into 3 groups: the 1st (control group) included 118 patients who underwent conventional traditional methods of treatment; in the 2nd group (main group I) there were 120 patients who, in combination with traditional methods of treatment, used PDT with a photosensitizer (PS) 0.05% methylene blue buffer solution (MB); and the 3rd group (main group II) included 122 patients where PDT was used in combination with traditional methods of treatment (0.05% methylene blue buffer solution was used as PS) and a CO 2 laser. Clinical, microbiological, morphological and planimetric methods have been investigated to assess the effectiveness of the method. Results: Photodynamic therapy with a light emitter ALT-Vostok- 03 is a rather effective non-invasive and sparing method of treating purulent wounds and serves as a rationale for the application of the method of photodynamic therapy in clinical practice for the treatment of local acute purulent-inflammatory processes in combination with a CO 2 laser and traditional methods of treatment. In patients of the main group, the normalization of temperature and heart rate was observed at 3.0 ± 0.5 days, a decrease in LII indices to the normal level was observed at 7.0 ± 0.5 days after the treatment. Analysis of the dynamics of clinical manifestations showed that the treatment of purulent wounds using PDT with a photosensitizer of the blizzard blue leads to a rapid decrease in perifocal inflammatory manifestations. Hyperemia of the skin around purulent wounds and a decrease in perifocal inflammation persisted for 3.5 ± 0.5 days, a decrease in local edema was noted for 2.0 ± 0.5 days. The average length of hospital stays for patients in the main group averaged 5.0 ± 2.5 bed-days. After 3-5 sessions of PDT with a photosensitizer MS in the main group, the microbial contamination decreased to a critical level, and after 6-8 sessions, no microbial growth was observed. Author α : Doctor of Medical Sciences, Professor, Head of the Department of Surgical Diseases of the Tashkent Medical Academy. e-mail: tma.tor@mail.ru Author σ : Assistant of the Department of Surgical Diseases of the Tashkent Medical Academy. e-mail: dr.alimurod@mail.ru Author ρ : Doctor of Medical Sciences, Professor of the Department of Surgical Diseases of the Tashkent Medical Academy. e-mail: olimboy.mavlyanov@tma.uz Conclusion: The combined use of PDT and CO 2 laser is the most effective, in comparison with traditional methods of treatment, which leads to earlier cleansing from pus, active formation of granulation tissue and shortening the time of complete epithelialization of the wound surface. Keywords: photodynamic therapy, photosensitizer, methylene blue, СО 2 laser, laser surgery, microbe, planimetry. I. I ntroduction espite the achievements of recent years in the field of microbiology, immunology, intensive work on the development and implementation of new antibacterial drugs, improvement of surgical techniques, the problem of treating purulent-inflammatory diseases of soft tissues does not lose its relevance [4,8,32,36]. This problem is compounded by the growing number of pathogenic microorganisms resistant to both antibiotics and some antiseptics [25,31]. In the general structure of surgical diseases, surgical infection is observed in 35 - 45% of patients. At the same time, up to 70-80% of these patients are admitted to hospitals for urgent indications. In the structure of postoperative complications, surgical infection ranges from 32 to 75% [1, 2, 23, 13, 19, 9, 37, 34, 35, 43]. These impressive figures convincingly indicate the relevance and unsolved problem of purulent infection in surgery, which is a very serious medical, social and economic problem that remains relevant today [29]. Despite the availability of various methods of treatment used in purulent surgery, it does not reduce the number of patients with surgical infection, which contributed to the introduction of a wide range of physical and physicochemical methods of local treatment of purulent soft tissue diseases [1, 14, 20, 40]. One of the promising areas of modern medicine in solving this problem is the use of laser treatment methods. Photodynamic therapy (PDT) is a unique medical technology: highly effective, sparing, organ- preserving, providing good cosmetic and functional results [26]. PDT is a relatively new method of treatment based on the use of drugs - photosensitizers (substances that are sensitive to light) and laser radiation with a certain wavelength corresponding to the absorption peak of the photosensitizer [17,24]. D 1 Year 2022 Global Journal of Medical Research Volume XXII Issue I Version I ( D ) F © 2022 Global Journals