Global Journal of Medical Research, F: Diseases, Volume 22 Issue 4

Using additional software SNPs & GO showed that 11 SNPs had a disease effect and 14 were neutral. For protein stability, I-Mutant software was used, all disease-related mutations resulting from SNPs&Go were predicted to decrease the protein stability with varied probabilities. The results were shown in Table (4). Table (4): Results of SNPs & GO, PHD SNP and I-Mutant software Mutation SNP & GO Prediction SNP & GO Probability SNP & GORI PHD Prediction PHD Probability PHD RI I-Mutant Prediction I-Mutant RI L4D Neutral 0.363 3 Neutral 0.439 4 Y6F Neutral 0.242 5 Disease 0.545 1 G11E Neutral 0.339 3 Disease 0.739 5 G11K Disease 0.509 0 Disease 0.782 6 Decrease 5 S24I Neutral 0.036 9 Neutral 0,215 6 A41D Disease 0.527 1 Disease 0.876 8 Decrease 7 E42A Disease 0.645 3 Disease 0.837 7 Decrease 3 R53Q Disease 0.570 1 Disease 0.862 7 Decrease 9 W60V Disease 0.623 2 Disease 0.843 7 Decrease 5 W85M Neutral 0.233 8 Neutral 0.233 5 P99E Neutral 0.288 4 Disease 0.548 1 V113C Neutral 0.471 1 Disease 0.681 4 A122F Neutral 0.477 0 Disease 0.733 5 rs199536408 G4D Deleterious 0 Deleterious -4.548 Probably Damaging 0.994 rs199536408 G198D Deleterious 0.001 Deleterious -6.729 Probably Damaging 1 rs368256121 V24I Deleterious 0.042 Deleterious -2.731 Probably Damaging 0.784 rs375283568 E168K Deleterious 0.001 Deleterious -3.978 Probably Damaging 1 rs375396766 H117L Deleterious 0.019 Neutral -1.931 rs375283568 E11K Deleterious 0.004 Deleterious -6.639 Probably Damaging 1 rs140543217 L163F Deleterious 0.009 Deleterious -3.907 Probably Damaging 0.992 rs140543217 Y6F Deleterious 0.037 Deleterious -3.52 Probably Damaging 1 rs375396766 P158L Deleterious 0.018 Deleterious -9.94 Probably Damaging 0.998 rs375396766 H117L Deleterious 0.019 Deleterious -3.974 Benign 0.002 rs374473331 G123E Deleterious 0 Deleterious -7.547 Probably Damaging 1 rs374473331 G82E Deleterious 0.001 Deleterious -2.778 Benign 0.005 rs143267384 E101V Deleterious 0.032 Deleterious -3.128 Benign 0.017 rs143267384 E60V Deleterious 0.044 Deleterious -13.647 Probably Damaging 1 rs370003137 S67P Deleterious 0.011 Deleterious -4.446 Benign 0.374 rs370003137 S26P Deleterious 0.036 Neutral 0 rs200808744 R53Q Deleterious 0.019 Deleterious -3.724 Probably Damaging 1 rs373921680 E42A Deleterious 0.001 Deleterious -5.639 Probably Damaging 1 rs370453859 G11E Deleterious 0.004 Deleterious -6.573 Probably Damaging 1 19 Year 2022 Global Journal of Medical Research Volume XXII Issue IV Version I ( D ) F © 2022 Global Journals Computational Analysis of Possibly Pathogenic Non-Synonymous Single Nucleotide Polymorphisms Variants in HGD Gene G123E Neutral 0.483 2 Disease 0.884 8 P158L Neutral 0.425 1 Disease 0.839 7