Global Journal of Medical Research, F: Diseases, Volume 22 Issue 4

24 Year 2022 Global Journal of Medical Research Volume XXII Issue IV Version I ( D ) F © 2022 Global Journals Computational Analysis of Possibly Pathogenic Non-Synonymous Single Nucleotide Polymorphisms Variants in HGD Gene 23. Titus, G.P., Mueller, H.A., Burgner, J., Rodríguez de Córdoba, S., Peñalva, M.A. and Timm, D.E., 2000. Crystal structure of human homogentisate dioxygenase. Nature structural biology, 7(7), pp. 542-546. 24. Vilboux, T., Kayser, M., Introne, W., Suwannarat, P., Bernardini, I., Fischer, R., O'Brien, K., Kleta, R., Huizing, M. and Gahl, W.A., 2009. Mutation spectrum of homogentisic acid oxidase (HGD) in alkaptonuria. Human mutation, 30(12), pp. 1611-1619. 25. Wilson, P.J., Ranganath, L.R., Bou ‐ Gharios, G., Gallagher, J.A. and Hughes, J.H., 2021. Expression of tyrosine pathway enzymes in mice demonstrates that homogentisate 1, 2 ‐ dioxygenase deficiency in the liver is responsible for homogentisic acid ‐ derived ochronotic pigmentation. JIMD reports, 58(1), pp. 52-60. 26. Zatkova, A. and Nemethova, M., 2015. Genetics of alkaptonuria–an overview Genetika alkaptonúrie– preh ľ ad. Acta Fac. Pharm. Univ. Comen. LXII, 11, pp. 27-32.