Global Journal of Medical Research, F: Diseases, Volume 22 Issue 6

Cystic Fibrosis– Is it Extremely Rare or Invariably Missed: An Observational Study in Bangladesh Scenario By M S Khaled, Firoza Akter, Jahangir Khan, Sayedul Islam & Md. Golam Dostogir Harun National Institute of Diseases of the Chest and Hospital (NIDCH) Abstract- Background: Cystic fibrosis (CF), the most common genetic disorder among the Caucasian population was believed to be extremely rare or non-existent in Indian subcontinent countries like Bangladesh. But the real scenario is not so infrequent as per belief. Objective: To introduce pilocarpine iontophoresis Sweat Chloride Test (SCT) for the first time in Bangladesh for the diagnosis of CF and to determine the phenotypic spectrum of the disease in Bangladeshi patients. Methods: A prospective observational study conducted over a period of 3 years including 400 patients (N=400) clinically suspected of CF and pilocarpine iontophoresis sweat chloride tests were performed using locally developed low-cost technology. Sweat chloride estimation was done by Schales and Schales method. Keywords: cystic fibrosis, sweat chloride, pilocarpine iontophoresis, bangladesh. GJMR-F Classification: DDC Code: 616.37 LCC Code: RC858.C95 CysticFibrosisIsitExtremelyRareorInvariablyMissedAnObservationalStudyinBangladeshScenario Strictly as per the compliance and regulations of: Global Journal of Medical Research: F Diseases Volume 22 Issue 6 Version 1.0 Year 2022 Type: Double Blind Peer Reviewed International Research Journal Publisher: Global Journals Online ISSN: 2249-4618 & Print ISSN: 0975-5888 © 2022. M S Khaled, Firoza Akter, Jahangir Khan, Sayedul Islam & Md. Golam Dostogir Harun. This research/review article is distributed under the terms of the Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0). You must give appropriate credit to authors and reference this article if parts of the article are reproduced in any manner. Applicable licensing terms are at https://creativecommons.org/licenses/by-nc-nd/4.0/.