Global Journal of Medical Research, F: Diseases, Volume 22 Issue 6

Table-4: Relationship between HRCT result of the participants and their SCT results (N=201) HRCT Result Positive SCT+Ve (n= 38) Borderline SCT±Ve (n= 9) Negative SCT-Ve (n= 154) P-Value Normal 2 (5.3 %) 0 (0.0 %) 12 (7.8 %) 0.605 Bronchiectasis 26 (68.4 %) 5 (55.6 %) 52 (33.8 %) <0.001 Consolidation 18 (47.4 %) 1 (11.1 %) 40 (26.0 %) 0.016 Consolidation/collapse 0 (0.0 %) 1 (11.1 %) 30 (19.5 %) 0.011 Air trapping/Mucus plugging 8 (21.1 %) 2 (22.2 %) 18 (11.7 %) 0.250 Cavity 8 (21.1 %) 2 (22.2 %) 46 (29.9 %) 0.515 The microbiological profile shown in table 5 reveals that Pseudomonas and Klebsiella were found to have highly statistically significant prevalence in the specimens of SCT positive result holders than other groups (p = 0.001). Table 5: Relationship between the microbiological profile of the participants and their SCT results (N=320) IV. D iscussion Cystic Fibrosis (CF), considered to be the most common genetic disorder among the Caucasian population had remained largely unrecognized in developing countries like Bangladesh. Clinical features of this disease individually resemble those of other common diseases in this country like asthma, pneumonia, tuberculosis, chronic diarrhea etc. and the diagnosis may be missed invariably and patients treated wrongly with frequent changing physicians (video-2). Due to low index of suspicion, physicians usually not consider CF in a differential diagnosis. On the other hand, due to unavailability of pilocarpine iontophoresis SCT in Bangladesh, physicians have to rely on patient’s clinical presentations for making a diagnosis and treating the patient. In a few centers, sweat collection is done for analysis by an indigenously wrapped sweating technique 15 where to whole body of the patient is wrapped with a long piece of polythene and heat generated by room heater for sweating which is not well established and validated rather hazardous often for pediatric patients and also inconsistency in sweat chloride results. Moreover, alternate procedures are no longer acceptable for the diagnosis of CF 16 . The present study has introduced an indigenously developed inexpensive technology for the diagnosis of CF by quantitative pilocarpine iontophoresis sweat chloride test Microbiological Profile Positive SCT+Ve (n= 38) Borderline SCT±Ve (n= 9) Negative SCT-Ve (n= 273) P-Value No growth 0 (0.0 %) 2 (22.22 %) 55 (20.14 %) 0.009 Pseudomonas 22 (57.89 %) 2 (22.22 %) 60 (21.97 %) <0.001 Streptococcus 7 (18.42 %) 2 (22.22 %) 112 (41.02 %) 0.017 Staphylococcus 9 (23.68 %) 4 (44.44 %) 118 (43.22 %) 0.070 H. Influenza 4 (10.52 %) 3 (33.33 %) 98 (35.89 %) 0.008 Klebsiella 17 (44.73 %) 0 (0.0 %) 55 (21.14 %) 0.001 Moraxella 0 (0.0 %) 0 (0.0 %) 25 (9.15 %) 0.096 Acinetobacter 1 (2.63 %) 1 (11.11 %) 19 (6.95 %) 0.513 Aspergillus 1 (2.63 %) 0 (0.0 %) 08 (2.93 %) 0.869 23 Year 2022 Global Journal of Medical Research Volume XXII Issue VI Version I ( D ) F © 2022 Global Journals Cystic Fibrosis– Is it Extremely Rare or Invariably Missed: An Observational Study in Bangladesh Scenario