Global Journal of Medical Research, F: Diseases, Volume 23 Issue 2

menu for T2DM individuals that complies with normal operating standards, this study aims to employ regional, easily accessible whole plant-based choices. Diet however, is a known modifier of and regulator of NFkB through phytonutrient and antioxidant formation, causing a down regulation of NFkB production and gene modulation that occurs from NFkB pathway. This down regulation has not been fully achieved with medications in management of non communicable diseases. Finally, while many individuals may have access to food, they could not have the money to pay for medical treatment. For these people with T2DM, using meals they are currently accustomed to promote health and wellness would be very beneficial. These research on dietary adjustment (exclusively Nigerian foods) in T2DM haven't received much attention, yet the results will aid T2DM patients' health outcomes. T2DM medications are not without dangers and negative effects (Siminialayi et al., 2006). When glycaemic management was improved for 3-5 years with pharmaceuticals, ADVANCE Collaborative Group (2008) and Ling et al. (2009) found that this did not lessen macrovascular consequences because of epigenetic alterations. This research seeks to assess the effectiveness of a purely Nigerian diet in helping people with type 2 diabetes mellitus lose weight and maintain excellent glycaemic control in the University of Port Harcourt Teaching Hospital, Rivers State, Nigeria. II. M aterials and M ethods a) Research Approach Ethical approval was sought and obtained from the Ethics Review Committee of the University of Port Harcourt (Annex 1) with reference number UPH/ CEREMAD/REC/MM71/001. Sixty study participants were randomly assigned and matched evenly into the two groups (Standard of Care-Control and Dietary Intervention-Treatment). These individuals were randomized into matched control (standard of care) and treatment (dietary calorie restriction intervention) groups. They were known diabetics who attended a diabetes clinic and were followed up for 24 full weeks (August 2021 to February 2022). Throughout the trial, the control group and the intervention group both reported their FBS on a biweekly basis. ANOVA was used to conduct a test of significance for each of the two sets of observations (within the control and intervention group). Then, to completely exclude the impact of variables on the treatment group, a more robust statistic with better experimental sensitivity, such as ANCOVA, was used to guarantee that significance in the treatment group is attributable to intervention (Kpolovie, 2010). Microsoft Office Excel 2017 was used for the graphics, and Statistical Packages for Social Science (SPSS) version 22.0 was used for the statistical analysis. For the analysis of the data, the study used the following statistics: descriptive statistics for cleaning the data, stem-and-leaf plots and box plots for spotting and eliminating outliers, Kolmogorov-Smirnov tests, and histograms for determining normality. The research issues and study hypotheses were addressed using crosstab and frequency, ANOVA and ANCOVA, and significant variables were submitted to post hoc or pairwise comparison tests (i.e. Bonferroni test). The Mann-Whitney U test was used for independent samples (such as anthropometric characteristics) and the Wilcoxon signed-rank test was used for dependent samples (such as FBS) to examine the statistical significance of the differences between means. The cutoff point for statistical significance between means was chosen at 0.05. Using Pearson's linear correlation, the associations between the indices were assessed, with the level of statistical significance set at p 0.05 at 95% confidence. b) Recruitments Participants were chosen from among the diabetes patients who visited the University of Port Harcourt, Nigeria's General Outpatient and Diabetes Clinics. Patients had to be known diabetics, 18 years of age or older, not be using any herbal, conventional, or complementary medications in the two weeks before to the study's start, and not be taking any drugs that are known to affect pancreatic or kidney function. Additionally, patients with poorly controlled blood sugar at the most recent routine clinical check, BMIs of >26 kg/m2 and 45 kg/m2, patients with pre-existing co- morbidities or complications of diabetes, patients who were critically ill, and patients who were taking drugs that affected the mind were disqualified. Each participant gave their agreement before the study's 60 participants were randomly assigned to the open label control (Standard of care) or intervention arms. The intervention group got a calorie-restricted meal made up of items that were cultivated nearby, whereas the control arm included diabetes patients who were taking at least one oral hypoglycemic medication. To make sure there was no statistically significant difference between the control and intervention groups, statistical tests were conducted. All trial participants underwent clinical evaluations and assessments of adherence and morbidity once per month. At least once a week, all participants were phoned on their cell phones to check in and address any issues that came up as the research went along. Participants whose clinical symptoms worsened were taken out of the trial and started receiving complete pharmacological therapy under the care of an endocrinologist until their circumstances 48 Year 2023 Global Journal of Medical Research Volume XXIII Issue II Version I ( D ) F © 2023 Global Journals Type 2 Diabetes Mellitus Remission in Patients with Ideal BMI in Rivers State, Nigeria