Global Journal of Medical Research, L: Nutrition & Food Science, Volume 22 Issue 2

18 Year 2022 Global Journal of Medical Research Volume XXII Issue II Version I ( D ) L © 2022 Global Journals Antihyperlipidemic Property of a Dietary Supplement of Moringa Oleifera Leaves and Pleurotus Ostreatus in Wistar Rats Stressed by Combination of Ethanol-Paracetamol TG TP (0,01%) D1P(500 mg/kg) D2P(1000 mg/kg) D3P(1500 mg/kg) 0 2 4 6 8 CREATININ (mg/dl) a,b,c Figure 7: Effect of the dietary supplement on creatinin activity (mg/dl) in the serum of rats stressed by the combination of ethanol (30% - 2g/kg) and paracetamol (750mg/kg) The values are expressed as mean ± SD. TG: Control group rats with food and water ad libitum, TP: stressed rats without treatment, D1P: dose of 500 mg/kg, D2P: dose of 1000 mg/kg, D3P: dose of 1500 mg/kg.a, b mean statistically different from D2P and D3P at p<0.05 (Bonferroni test) IV. C onclusion A dietary supplement of Moringa oleifera leaves and Pleurotus ostreatus in wistar rats shows that the powders of M. oleifera leaves and P. ostreatus mixture have an antihyperlipidemic effect as it significantly lowers total and LDL cholesterol levels in rats stressed by combination of ethanol and paracetamol. The dose 1000 mg/kg is most appropriate for chemically stressed animals. FMP16 would have no effect on albumin and testosterone levels. A cknowledgements The authors would like to thank the Biotechnology Laboratory of the University Cheikh Anta Diop of Dakar, Senegal, and the Faculty of Science, the FODRUS-LAPHER-Biotech of the University of Yaoundé I, Cameroon. The project was part of a scholarship provided to Fatou Corka KANE through Africa for Innovations, Mobility, Exchange, Globalization and Quality (AFIMEGQ) program sponsored by the European Commission’s EACEA program. Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper. R eferences R éférences R eferencias 1. A.Mbora, G.Mundia, and S.Muasya, Combating Nutrition with Moringa oleifera, World Agroforestry Centre, Nairobi, Kenya, (2004). 2. Abou-Elezz Fouad Mohammed, L. Sarmiento- Franco, R. Santos-Ricalde, and J.F.Solorio Sanchez, “The nutritional effect of Moringa oleifera fresh leaves as feed supplement on Rhode Island Red hen egg production and quality,” Tropical Animal Health and Production, vol.44, no.5, pp. 1035–1040, (2012). 3. Abrams D I, Couey P, Shade B S, Kelly M E, Elias N K and Stamets P, Anti-hyperlipidemic effects of Pleurotus ostreatus (oyster mushrooms) in HIV- infected individuals taking antiretroviral therapy, BioMed Central Complementary and Alternative Medicine, 11: 60, 1-8, (2011). 4. Adedapo A, Mogbojuri O M, and Emikpe B O, Safety evaluations of the aqueous extract of the leaves of Moringa oleifera in rats, Journal of Medicinal Plants Research, 3: 8, 586-591, (2009) 5. Akhtar A H, Ahmad K U, Anti-ulcerogenic evaluation of the methanolic extracts of some indigenous medicinal plants of Pakistan in aspirin-ulcerated rats, Journal of Ethnopharmacology, 46: 1, 1-6, (1995). 6. Alam N, Amin R, Khan A, Ara I, Ja Shim M, Woong Lee M and Soo Lee T, Nutritional Analysis of Cultivated Mushrooms in Bangladesh - Pleurotus ostreatus, Pleurotus sajor-caju, Pleurotus florida and Calocybe indica, Mycobiology, 36:4, 228-232, (2008). 7. Azaizeh H, Fulder S, Khalil K, Said O. Ethanomedicinal knowledge of local Arab