Global Journal of Medical Research, L: Nutrition & Food Science, Volume 22 Issue 2

research is ongoing, and it will be continued for years to come. So, these specific neuropsychological tests will be validated for the Greek population soon. Another limitation is the limited number of participants (n=30) because this is a pilot study testing the effects of EH EVOO, the feasibility of the present research protocol. There had been no previous evidence presented about the benefits of EH EVOO, and olive oil in general, in protecting the cognition and mental health of patients with MS. So, the innovation of the present pilot study is that these results can expand the research in this field and encourage the use of EVOO in holistic treatments of MS. For this reason, studies with increased sample size and even more bold approaches will be useful confirming the present study’s results and identifying the specific mechanisms by which olive oil offers its benefits. Declarations Acknowledgements: We would like to offer our special thanks to Family Company Ellis farm (https.//ellis- farm.com/) for the Donation of the Health Claim EVOO High Phenolic Early Harvest Eliama D.V. Gold as on this important research project. Furthermore, many thanks for Dr Prokopis Magiatis. Associate Professor at Faculty of Pharmacy, National and Kapodistrian University of Athens (Laboratory of Pharmacognosy and Natural Products Chemistry) for all certificates of EVOO. Funding: The present study and the authors were not funded. Conflicts of interest: The authors declare that they have no conflict of interest. Ethics approval: The study protocol has been approved by Bioethics Committee of Greek Association of Alzheimer’s Disease and Related Disorders. Consent to participate: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the Declaration of Helsinki 1964 and was approved by the local ethics committee. All the participants gave informed consent prior to their inclusion in the study. Consent for publication: All the authors have consented for the publication of the study. Availability of data and material: Data available upon duly justified request. Conflicts of interest: none R eferences R éférences R eferencias 1. National Multiple Sclerosis Society. Symptoms and Diagnosis, www.nationalmssociety.org/Symptoms- Diagnosis (accessed 20 August 2020). 2. Dobson, Ruth, and Gavin Giovannoni. "Multiple sclerosis–a review." Eur J Neurol . 2019; 26(1): 27-40. doi:10.1111/ene.13819. 3. Lassmann H. Pathology and disease mechanisms in different stages of multiple sclerosis. 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