Global Journal of Science Frontier Research, G: Bio-Tech & Genetics, Volume 22 Issue 2

Global Journal of Science Frontier Research: G Bio-Tech & Genetics Volume 22 Issue 2 Version 1.0 Year 2022 Type: Double Blind Peer Reviewed International Research Journal Publisher: Global Journals Online ISSN: 2249-460x & Print ISSN: 0975-587X Modulation of Warfarin Sodium into Warfarin Potassium for Patients with Hypertension Strictly as per the compliance and regulations of: © 2022. Al-Baraa Akram. This research/review article is distributed under the terms of the Attribution-NonCommercial- NoDerivatives 4.0 International (CC BY-NC-ND 4.0). You must give appropriate credit to authors and reference this article if parts of the article are reproduced in any manner. Applicable licensing terms are at https://creativecommons.org/licenses/by-nc- nd/4.0/. By Al-Baraa Akram De Montfort University Abstract- Warfarin is an oral anticoagulant drug that has a prolonged duration of action with delayed onset of action; its chemical structure contains sodium atoms, which may be hazardous to hypertensive patients. To solve this problem, sodium atom can be substituted with potassium or lithium atom which can help the patient to relieve hypertension in addition to it essential role as an anticoagulant. Another advantage of this preparation is that it can be used as an antidote against digitalis toxicity, but the warfarin interactions with other drugs are still the same as a cytochrome P450 inhibitor. Keywords: warfain, hypertension, international normalized ratio, therapeutic window, clinical trials, pharmaco-genomics, CYP2C9*3. GJSFR-G Classification: DDC Code: 616.132 LCC Code: RC685.H8 ModulationofWarfarinSodiumintoWarfarinPotassiumforPatientswithHypertension