Global Journal of Science Frontier Research, G: Bio-Tech & Genetics, Volume 22 Issue 2

which can lead to limb necrosis and even gangrene. Its natural counterpart, purpurafulminans, occurs among children homozygous of protein C mutations. j) Osteoporosis After initial reports which claim that warfarin reduces calcium bone, there is a link between warfarin use and osteoporosis-related fracture. For women taking warfarin for deep venous thrombosis, the risk of rib fractures and vertebral fractures is increased; other fracture types don't occur more commonly. II. M aterials and M ethods To manipulate the reaction of converting warfarin sodium into warfarin potassium, you need to ask some simple questions: You have an organic compound (warfarin) C 19 H 15 NaO 4 with a molecular weight of 330.3 g/mol; it contains a sodium atom and must replace with an atom of potassium. The IUPAC name of warfarin sodium is sodium 2-oxo-3-(3-oxo-1-phenylbutyl)-2H-chromene-4- olate. Modulation of Warfarin Sodium into Warfarin Potassium for Patients with Hypertension © 2022 Global Journals 1 Year 2022 6 Global Journal of Science Frontier Research Volume XXII Issue ersion I VII ( G ) Figure 8: Chemical structure of warfarin sodium with a molecular formula C 19 H 15 NaO 4 and its molecular weight of 330.3 g/mol. It is a crystalline powder. Used as an anticoagulant and rodenticide Which is better to replace the sodium atom with a potassium atom within this organic compound? Is the simple substitution reaction preferred or the double substitution reaction? 1. If the simple substitution reaction was better, how can you get elementary potassium? 2. If the double replacement reaction is better, what is the concentration of potassium hydroxide required to complete the reaction? And is it better for substitution reactions or any potassium salt e.g., potassium iodide is better? To answer these questions, you need to do the following: Prepare an acid like hydrochloric acid to convert ONa group into OH, filter papers, beaker, conical flask, potassium base e.g., potassium hydroxide and mortar 1. In a mortar, grind 100 mg warfarin sodium tablets properly until you get the powder form to increase the surface area as shown in figure 9 below