Global Journal of Science Frontier Research, G: Bio-Tech & Genetics, Volume 22 Issue 2

Global Journal of Science Frontier Research: G Bio-Tech & Genetics Volume 22 Issue 2 Version 1.0 Year 2022 Type: Double Blind Peer Reviewed International Research Journal Publisher: Global Journals Online ISSN: 2249-460x & Print ISSN: 0975-587X Strictly as per the compliance and regulations of: © 2022. Hannah Beird, Alexander J. Lazar & Danh Truong. This research/review article is distributed under the terms of the Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0). You must give appropriate credit to authors and reference this article if parts of the article are reproduced in any manner. Applicable licensing terms are at https:// creativecommons.org/licenses/by-nc-nd/4.0/. The Genomics of Liposarcoma: A Review and Commentary By Hannah Beird, Alexander J. Lazar & Danh Truong UT MD Anderson Cancer Center GJSFR-G Classification: DDC Code: 611.73 LCC Code: QM151 TheGenomicsofLiposarcomaAReviewandCommentary Liposarcomas are Adipocytic Soft Tissue Sarcomas- Soft tissue sarcomas (STS) are malignancies that show mesenchymal and neuroectodermal differentiation and thus most often resemble supportive and connective tissue including fat, blood vessels, muscle, bone, tendons, and nerves. Over 70 subtypes of sarcomas exist and pathologists have classified these broadly according to the degree to which they resemble differentiated cell types (Figure 1) 1 . This review will focus on the most common subset of STS in adults, “liposarcoma”, which are tumors with histological features of specialized fat cells. Liposarcoma are broken down into several subtypes. The four with the highest incidence are: well-differentiated liposarcoma (WDLPS), dedifferentiated liposarcoma (DDLPS), myxoid liposarcoma (MLPS), and pleomorphic liposarcoma (PLPS) 1 . Overall survival is highest for MLPS, followed by WDLPS and DDLPS, and then PLPS 2-4 (Figure 2). While WDLPS occurs predominantly in the deep soft tissues of the limbs and retroperitoneum, DDLPS is located mostly in the retroperitoneum. MLPS and PLPS are preferentially located within the limbs 5 . Despite these broad categories, liposarcoma can also have mixed phenotypes and is often further subdivided into even more rare entities with other ultra-rare features. For instance, pleomorphic MLPS has attributes of both PLPS and MLPS 6,7 .