Global Journal of Science Frontier Research, G: Bio-Tech & Genetics, Volume 22 Issue 2

Table 1: TC/AG Fibonacci and Lucas analysis for real NA1000 genome and synthetic Caulobacter 2.0. TC/AG Real genome NA1000 TC/AG Synthetic genome CAULOBACTER 2.0 Fibonacci Lucas Fibonacci Lucas 3 1580254 1582201 0.9987694357 3 1582201 1580254 1.00123208 3 290047 293417 0.9885146396 3 293417 290047 1.011618807 5 1346353 1346512 0.9998819171 4 993497 994619 0.9988719299 5 239292 242875 0.9852475553 4 194318 198624 0.9783208474 8 924521 926003 0.9983995732 7 1186993 1186953 1.0000337 8 168546 172325 0.9780705063 7 209444 211890 0.9884562745 13 650861 652564 0.9973902943 11 661049 662784 0.9973822542 13 120565 124586 0.9677251055 11 123932 128203 0.966685647 21 377329 378580 0.9966955465 18 489878 492487 0.9947023982 21 74278 77737 0.9555038141 18 92499 96693 0.9566256089 34 188645 190539 0.9900597778 29 232050 233697 0.9929524127 34 40816 44246 0.9224788681 29 48895 52692 0.9279397252 55 71250 72070 0.9886221729 47 104152 104668 0.9950701265 55 18131 20974 0.8644512253 47 24743 27988 0.8840574532 89 19694 19535 1.008139237 76 30804 31161 0.9885433715 89 6300 8172 0.7709251101 76 9026 11226 0.8040263674 Figure 1: Comparing TC/AG Fibonacci and Lucas distances in real and synthetic Caulobacter genomes ( regular-reverse distances weighted by the length of the genome, see detailed data in suplementary materials) example of weighting by the length of the genome computing here the case of synthetic caulobacterium genome (case of the first Fibonacci resonance of length = 3 nucleotides): regular - reverse distance = 290047-293417 = ¯3370 weighting by the genome length : ¯3370÷785750 = ¯0.004288895959 normalization multiply by 1000000 = 1000000ׯ0.004288895959 = ¯4288.895959 = -4289 (see more details in suplementary materials page 2). In the figure on the left, the average ratio of weighted distances by genome length between real genome and synthetic genome is 14.39 for TC/AG Fibonacci resonances (see supplementary materials). For information, the same ratio related to Lucas TC/AG is = 14.345484 Computing details real genome abs. Distances: 482 40 367 422 310 469 203 39 synthetic genome abs. Distances: 4289 4560 4810 5118 4403 4366 3619 2383 cumulating real genome abs. Distances: 2332 © 2022 Global Journals 1 Year 2022 38 Global Journal of Science Frontier Research Volume XXII Issue ersion I VII ( G ) Epigenetics Theoretical Limits of Synthetic Genomes: The Cases of Artificials Caulobacter ( C. eth-2.0), Mycoplasma Mycoides (JCVI-Syn 1.0, JCVI-Syn 3.0 and JCVI_3A), E-coli and YEAST chr XII